This document presents a comprehensive framework for solid regulatory governance of large-scale food fortification (LSFF), a key strategy to addressing micronutrient deficiencies. It identifies six core pillars that are critical for the effective design and implementation of LSFF initiatives across diverse country contexts: collecting data and scientific evidence to identify the problem and policy options, designing policies and regulations, ensuring adequate authorisation processes, implementing supervision and enforcement measures, building capacity for continuous improvement, and incentivising stakeholder performances. It builds on the recommendations and principles on regulatory policy developed by the OECD Regulatory Policy Committee (RPC) as well as case studies. The framework aims to assist policymakers and regulators in evaluating their legal frameworks and offers insights on how to improve regulatory practices and outcomes. It also explores how the implementation of each of these pillars could be assessed through the development of indicators and presents findings from selected pilot country studies.