At an OECD expert meeting on ecotoxicology and environmental fate testing, the applicability of the well-established OECD Test Guideline 305 (TG 305) for the testing of bioaccumulation of nanomaterials in fish was discussed. It was agreed that the octanol-water partition coefficient test is problematic for many nanomaterials and that an alternative trigger to decide on the conduct of bioaccumulation testing was needed, as well as appropriate guidance when fish bioaccumulation testing is performed.
First commenting round on Assessing the Apparent Accumulation Potential of Nanomaterials
- Submission period
- 25 July - 31 December 2024
Background public consultation
Project description
This project is focused on the applicability of TG 305 to nanomaterials. The experimental work has been supported by the H2020 project Gov4Nano (Europe’s Horizon 2020 Research and Innovation Programme, Grant Agreement No. 814401) and Spanish resources. The aim of the project was to develop a Guidance Document that allows using TG 305 for nanomaterials applying the aqueous and dietary methods. This guidance only becomes relevant once it has been decided that a fish test is needed. The Guidance Document will apply for all nanomaterials, but current technical limitations for the determination of non-metal based nanomaterials in feed and fish tissues, hamper detailed guidance in some sections for these nanomaterials compared to metal-based nanomaterials.
This document was led by Spain with contributions from the Netherlands and the United Kingdom and benefitted from the inputs of the Joint WNT/WPMN Expert Group on Ecotoxicity and Environmental Fate Testing.
How to contribute
The draft Guidance Document on Assessing the Apparent Accumulation Potential of Nanomaterials is currently under a commenting round by the Working Party of the National Coordinators of the Test Guidelines Programmes and open for comments from the public at the same time. Interested parties are invited to contact their National Coordinators at least a week before 31 December 2024.
