Test No. 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays

DOI:https://dx.doi.org/10.1787/9789264203907-en

This Test Guideline describes an in vivo assay that detects chemicals that may induce gene mutations. In this assay, transgenic rats or mice that contain multiple copies of chromosomally integrated plasmid or phage shuttle vectors are used. The ...



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