Test No. 476: In Vitro Mammalian Cell Gene Mutation Tests using the Hprt and xprt genes

DOI:https://dx.doi.org/10.1787/9789264264809-en

The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT), and at a transgene of xanthineguanine phosphoribosyl transferase...



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