Test No. 429: Skin Sensitisation

Local Lymph Node Assay

DOI:http://dx.doi.org/10.1787/9789264071100-en

The basic principle underlying the Local Lymph Node Assay (LLNA) in mouse is that sensitizers induce a primary proliferation of lymphocytes in the auricular lymph nodes draining the site of chemical application. This proliferation is proportional to ...



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